TY  - BOOK
AU  - Norman,R.O.C.
AU  - Coxon,J.M.
TI  - Principles of organic synthesis
SN  - 0751401269 (acidfree)
U1  - 547.2 NOR 
PY  - 1993///
CY  - London, New York
PB  - Blackie Academic & Professional
KW  - Organic compounds
N1  - Includes index; 1. Chemical thermodynamics -- 2. Molecular structure -- 3. Chemical kinetics -- 4. Mechanism -- 5. Stereochemistry -- 6. Formation of carbon-carbon bonds: organometallic reagents -- 7. Formation of aliphatic carbon-carbon bonds: base-catalyzed reactions -- 8. Formation of aliphatic carbon-carbon bonds: acid-catalyzed reactions -- 9. Pericyclic reactions -- 10. Formation of aliphatic carbon-nitrogen bonds -- 11. Electrophilic aromatic substitution -- 12. Nucleophilic aromatic substitution -- 13. Aromatic diazonium salts -- 14. Molecular rearrangements -- 15. Reagents containing phosphorus, sulfur, silicon or boron -- 16. Photochemical reactions -- 17. Free-radical reactions -- 18. Organotransition metal reagents -- 19. Oxidation -- 20. Reduction -- 21. The synthesis of five- and six-membered heterocyclic compounds -- 22. The syntheses of some naturally occurring compounds
N2  - The purpose of this book is to show how mechanistic principles can be applied both to acquiring a knowledge of organic synthetic processes and to planning the construction of organic compounds. It is designed for those who have had no more than a brief introduction to organic chemistry and who require a broad understanding of the subject; The book is in two parts. In Part I, reaction mechanism is set in its wider context of the basic principles and concepts that underlie chemical reactions: chemical thermodynamics, structural theory, theories of reaction kinetics, mechanism itself, and stereochemistry; In Part II, these principles and concepts are applied to the formation of particular types of bonds, groupings, and compounds: for example, how small molecules can be built on to give larger ones by the construction of new carbon-carbon bonds, or how one functional group can be transformed into another. The final chapter in Part II describes the planning and detailed execution of the multi-step syntheses of several complex naturally occurring compounds; ; There have been numerous important developments since the second edition of this book was published 15 years ago, and every chapter has been brought up to date to include them; Among the more notable are: the stereochemical control of reactions, reflecting the need to synthesize efficiently compounds with several asymmetric centres; the use of organotransition-metal reagents, leading to a new chapter; the exploitation of lithium diisopropylamide (LDA) as a base in the formation of new C-C bonds; free-radical reactions for the synthesis of C-C bonds; uses of organosilicon compounds; and subtle new protective and condensing reagents in polypeptide synthesis; The text is extensively cross-referenced and a detailed index is included
ER  -